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The synergy arises from the convergence of two independent second messenger systems cAMP/PKA from GHRHR and phospholipase C/calcium from GHS-R1a at the level of GH vesicle exocytosis

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10.1021/acs.chemrev.3c00392 239 ZhangX.XuC.JiL.ZhangH

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The phase 2 data suggest that if the priority is body weight reduction in obesity without diabetes, higher dosing arms like 12 mg may be appropriate for exploration

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